The only game my mom ever played was New Super Mario Bros. and she got to world 5 before quitting. I have Big Brain Academy, and its better than I expected it to be...my brain weighs 1,172 grams! And I've only had the game for a day!
Eh, I'm not sure if handhelds would work...there were just two games Tetris Attack (SNES, and it was a Mario tetris :wub and Tetrisphere where it's tetris in a sphere and you try to get to the center of the sphere, to let this little robot get out. It's for N64.