I haven't uploaded my school for viewing yet, but one room is a combination library/geography/science room and the other is tea-tasting around the world (all part of a master plan!!).
I saw a cool school online that had a fibre arts class, with looms and sewing machines and knitting baskets (and a lot of original patterns, too!). Others have done cooking classes, or an art room.
...and now here I go just riffing: you could maybe try doing a DJ class, with records and DJ decks, or plain ol' music appreciation with a variety of stereos. A class for tailors. An animal-care class would be cute, or a farming classroom. Woodworking/upholstery, an auto-body shop, a barber school (or a salon class), a greenhouse, a class for crime-fighting superheroes, a mushroom-appreciation seminar. A clock-repair class. Bartender school.