Yes, once in New Leaf. Thought she looked cool online, but shortly after I got her I found that the way her eyes looked on the model bothered me. Replaced her soon after.
When I saw Whitney in New Horizons for the first time, I thought her offset pupils were a designer error, and then I found out later that she's always been that way. Some other wolf villagers share this trait as well (Chief, Fang & Vivian), though I can kind of understand why some (especially those with OCD) would be bothered by it. I don't think it would look weird if their pupils were centered towards the nose like the other wolf villagers. Look at Audie for example. Her pupils rest in the center by default, and her eyes in general sort of resemble Whitney's:
...and not to sound biased, but Audie is my favorite out of the NH newcomers, so of course I'm not going to say she's ugly.