I can be sarcastic myself, but I still tend to take other people's sarcasm very literally -- unless vocal inflection or sheer absurdity make it blatantly obvious that it's not supposed to be taken literally. People basically have to be as subtle as a jackhammer with their humor for me to "get it."
As for the OP, I, too have had troubles with my condition again. I've had lifelong troubles socially, especially with tact, friendships, and fellowship. The latest episode was bad enough that I'm actually leaving a church denomination over it (that, and some doctrinal differences). I cope/receive help by leaving social situations that repeatedly cause frustration or lack of mutual understanding, and finding ones that seem to be better. Sometimes this backfires, however, if the one I found that seemed to be better, is only better for about 1-2 years before it also becomes intolerable.
I've come to accept that I may never have a traditional friendship, and that I'll probably just always have to "stay in the background" when it comes to church/faith. At least my marriage is good!