- Production Group No. 2 oversee and produce games developed by external studios and published by Nintendo, such as the Kirby, Xenoblade Chronicles, and Fire Emblem series.
- Production Group No. 3 develops the main The Legend of Zelda series.
- Production Group No. 4 develops casual and experimental games such as 1-2-Switch, Nintendo Labo, Ring Fit Adventure, Big Brain Academy: Brain vs. Brain, Jump Rope Challenge, Game Builder Garage, Nintendo Switch Sports and Everybody 1-2-Switch!
- Production Group No. 5, with group manager Aya Kyogoku, develops the Animal Crossing and Splatoon series.
- Production Group No. 6 oversee and produce games developed by external studios and published by Nintendo, such as the Paper Mario, Metroid Prime and Luigi's Mansion series.
- Production Group No. 7 co-develops 2D Metroid games with MercurySteam and Famicom Detective Club games with MAGES.
- Production Group No. 8, also known as Nintendo EPD Tokyo, develops 3D Super Mario games.
- Production Group No. 9 develops the Mario Kart series and also worked on Arms.
- Production Group No. 10 develops 2D Super Mario games (including the Super Mario Maker series) and the Pikmin series.
- Smart Device Production Group, with group manager Hideki Konno, develop smartphone games alongside other EPD groups as well as produce games by external studios.