I'm gonna say no, I understand why Nuzlocke's are appealing, but I don't know that I have the heart to do it. At the very least, I would only consider doing the modified version where "dead" Pokemon just go into the PC until the post-game rather than actually are released into the wild again.
I'll do it, but not on my first playthrough. I want to really enjoy the game and catch everything new, I don't want to worry about following nuzlocke rules and I'd rather do it on a second run when I know a little more about the game. I tend to plan my nuzelocks the best that I can. And it's a good way to keep the same game fresh through multiple runs.